Background: Tuberculosis (TB) is a major global health problem, which has been ranked as the second leading cause of death from an infectious disease worldwide. Diagnosis based on cultured specimens is the reference standard, however results take weeks to process. Scientists are looking for early detection strategies, which remain the cornerstone of tuberculosis control. Consequently there is a need to develop an expert System that helps medical professionals to accurately and quickly diagnose the disease. Artificial Immune Recognition System (AIRS) has been used successfully for diagnosing various diseases. However, little effort has been undertaken to improve its classification accuracy.Objectives: In order to increase the classification accuracy of AIRS, this study introduces a new hybrid System that incorporates a support vector machine into AIRS for diagnosing tuberculosis.Patients and Methods: Patient epacris reports obtained from the Pasteur laboratory of Iran were used as the benchmark data set, with the sample size of 175 (114 positive samples for TB and 60 samples in the negative group). The strategy of this study was to ensure representativeness, thus it was important to have an adequate number of instances for both TB and non-TB cases. The classification performance was measured through 10-fold cross-validation, Root Mean Squared Error (RMSE), sensitivity and specificity, Youden’s Index, and Area Under the Curve (AUC). Statistical analysis was done using the Waikato Environment for Knowledge Analysis (WEKA), a machine learning program for windows.Results: With an accuracy of 100%, sensitivity of 100%, specificity of 100%, Youden’s Index of 1, Area Under the Curve of 1, and RMSE of 0, the proposed method was able to successfully classify tuberculosis patients.Conclusions: There have been many researches that aimed at diagnosing tuberculosis faster and more accurately. Our results described a model for diagnosing tuberculosis with 100% sensitivity and 100% specificity. This model can be used as an additional tool for experts in medicine to diagnose TBC more accurately and quickly.

Uplift Modeling aims to detect subgroups in a population with a specific response or reaction to an action taken on the targeted group. In these models, the Treatment set contains objects that have been exposed to some action, such as a marketing campaign or clinical treatment, while in the Control set, they have not. In this study, a novel Artificial Immune System-based model was designed using an AIRS classifier to solve uplift modeling problems with improved efficiency. In this approach, a predictive model was built for estimating the conditional probability of receiving the desired response from the subpopulation that has taken the action over the relevant probability of the sub-population that has not taken the action. The proposed model was tested on the Hillstorm-visit-w dataset. Experimental results showed a 138 percent improvement in the area under the uplift curve which is a measure to assess an uplift model's performance.

Artificial Immune System (AIS) is one of the most meta-heuristic algorithms to solve complex problems. With a large number of data, creating a rapid decision and stable results are the most challenging tasks due to the rapid variation in real world. Clustering technique is a possible solution for overcoming these problems. The goal of clustering analysis is to group similar objects. AIS algorithm can be used in data clustering analysis. Although AIS is able to good display configure of the search space, but determination of clusters of data set directly using the AIS output will be very difficult and costly. Accordingly, in this paper a two-step algorithm is proposed based on AIS algorithm and hierarchical clustering technique. High execution speed and no need to specify the number of clusters are the benefits of the hierarchical clustering technique. But this technique is sensitive to outlier data. So, in the first stage of introduced algorithm using the proposed AIS algorithm, search space was investigated and the configuration space and therefore outlier data are determined. Then in second phase, using hierarchical clustering technique, clusters and their number are determined. Consequently, the first stage of proposed algorithm eliminates the disadvantages of the hierarchical clustering technique, and AIS problems will be resolved in the second stage of the proposed algorithm. In this paper, the proposed algorithm is evaluated and assessed through two metrics that were identified as (i) execution time (ii) Sum of Squared Error (SSE): the average total distance between the center of a cluster with cluster members used to measure the goodness of a clustering structure. Finally, the proposed algorithm has been implemented on a real sample data composed of the earthquake in Iran and has been compared with the similar algorithm titled Improved Ant System-based Clustering algorithm (IASC). IASC is based on Ant Colony System (ACS) as the meta-heuristics clustering algorithm. It is a fast algorithm and is suitable for dynamic environments. Table 1 shows the results of evaluation. The results showed that the proposed algorithm is able to cover the drawbacks in AIS and hierarchical clustering techniques and the other hand has high precision and acceptable run speed.